Cyclophosphamide MOA, Adverse Side Effects Like Cardiotoxicity, Mortality Rate

 

I am highlighting Cyclophosphamide as an example of how dangerous "cancer medications" can be. But first I will tell you about the drug's MOA.

 Mechanism of Action of Cyclophosphamide

Cyclophosphamide starts to work by first damaging the DNA of cancerous cells. The drug interrupts the cell cycle in a nonphase specific way. It hinders cell division by creating cross-linkages.

Common Side Effects

The most common side effects include nausea, vomiting, loss of appetite or weight, stomach pain, diarrhea, hair loss, sores on the tongue or mouth, changes in skin color, changes in color or growth of toe or finger nails.

Adverse Side Effects

Adverse side effects may include sore throat, fever, chills, poor or slow injury healing, unusual bleeding or bruising, black, tarry stools, painful urination or red urine, rash, hives, itching, problem swallowing or breathing, breathlessness, cough, swelling in the legs, ankles, or feet, chest pain, yellowing of the skin or eyes.

Cyclophosphamide might also boost your risk of developing other cancers as well as cardiotoxicity.

There are some drugs that have been assigned a "lifetime dose" due to their toxic potency; if you accumulate beyond that total dose, you risk dying! 

Cyclophosphamide, which is called Cytoxan (brand name), and is also commonly referred to as a "cytotoxic agent," because of its toxic effect on several types of cells, good and bad. The drug is used to reduce the danger of early-stage breast cancer from returning after surgery, and treat cancer of the blood, ovaries, lymph system, and nerves. Here are some vital figures worth noting, some straight from major sources:

  • Medicines.org.uk states: "Anaphylactic reactions including those with fatal outcomes have been reported in association with cyclophosphamide." 
  • The government site NCBI contributes: "The incidence of acute heart failure is anywhere between 7% and 33% of patients receiving a total dose of more than 150 mg/kg cyclophosphamide. Fatal cyclophosphamide cardiomyopathy varies between 2% and 17% depending on different dosing regimens and patient populations."
  • According to a retrospective study, researchers found a fatality rate of 40% in participants treated with cyclophosphamide for ILD-linked (interstitial lung disease) ARF (BioMedCentral).

In conclusion, if the cancer you are combating doesn't kill you, the drug such as cyclophosphamide may end up causing your demise; wouldn't you prefer a much safer manner to treat your cancer without the risk of death? Because so many Americans are "wired" mentally to rely heavily on drugs for everything, from treating headaches, heartburn, to cancer, this overwhelming reliance on potent medications partially explains the number of yearly cancer-related deaths.



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